According to a study conducted jointly by researchers in France and the United States, the clinical results of infectious endocarditis caused by Staphylococcus aureus are significantly worse than the results of endocarditis caused by other Pathogens.

The aim of this cohort study was to determine the clinical features, echocardiography data and prognostic characteristics of infectious endocarditis caused by S. aureus in comparison with other micro- pathogenic organisms.

The study always included 194 patients with an established diagnosis of infectious endocarditis. It turned out that in cases where endocarditis was caused by S. aureus, a more severe course was noted, a shorter duration of symptoms before the diagnosis of infective endocarditis and a greater likelihood of endocarditis on the right side. In patients with endocarditis caused by S.aureus, severe sepsis, multiple organ failure and severe neurological disorders were more likely to occur in the acute phase of the disease. These patients were often admitted to the intensive care unit and the intensive care unit.

Echocardiographic data were similar in all patients, regardless of the etiological factor causing endocarditis, although patients who had S.aureus isolated experienced less severe valve regurgitation and fewer cases of damage spreading to other valves.

The nosocomial mortality rate in patients with endocarditis caused by S. aureus was more than 3 times that of patients with endocarditis caused by other pathogenic microorganisms (34% vs 10%, p is less than 0.001), and the 36-month survival rate was lower in patients with endocarditis caused by S.aureus compared to other pathogens (47% vs 68%, p = 0.002). Multiple analyzes have shown that infectious endocarditis caused by Staphylococcus aureus is a predisposing factor for higher nosocomial mortality and overall mortality.

Thus, endocarditis caused by S. aureus is characterized by a higher incidence of severe sepsis, pronounced neurological disorders and multi-organ failure, leading to higher mortality. To obtain the maximum therapeutic effect, it is necessary to start treatment of infectious endocarditis as soon as possible and, if possible, to carry out surgical intervention.