As you know, the colonization of Helicobacter pylori is a risk factor for the development of gastric adenocarcinoma, however, the degree of risk and the relationship of colonization with the anatomical location, the under -histological type and prescription of the malignant process at the time of detection are still unclear.

To clarify the above questions, F. Kamangar et al. (USA) A prospective case-control study was carried out. The work included data from patients selected from 29,133 men aged 50 to 69 who participated in a cancer prevention study with α-tocopherol and β-carotene preparations. The relationship between seropositivity for H. pylori, defined as seropositivity for whole cells of the microorganism or the CagA antigen, and the development of adenocarcinoma of different parts of the stomach has was determined using a conditional logistic regression model.

For the period from 1985 to 1999. in 243 study participants, an adenocarcinoma of the stomach was revealed: in 61 - in the cardiac section and in 173 - in the non-cardiac sections. The control group consisted of 234 men of the corresponding age. Results showed that seropositivity for H. pylori was accompanied by an increased risk of developing cancer of the non-cardiac sections of the stomach (adjusted odds ratio (OR) 7.9; confidence (95% CI 3-20.9) and a decreased risk of developing heart service cancer (adjusted OR 0.31; 95% CI 0.11-0.89). There was no statistically significant relationship between seropositivity for H. pylori and the prescription and histological subtype of the malignant process.

The authors' calculations showed that the absolute risks of developing adenocarcinoma of the non-cardiac and cardiac sections of the stomach in the context of H. pylori colonization were 63 and 12 per 100,000 person-years, whereas these parameters in individuals not colonized by the microorganism were 8 and 37 per 100,000 person-years, respectively.

Colonization of H. pylori is an important risk factor for the development of cancer of the non-cardiac sections of the stomach, but it reduces the risk of developing cancer of the heart section.. The protective effect revealed by this micro-organism against the development of cancer of the cardiac section of the stomach calls into question the need to eradicate H. pylori by absence of erosive-ulcerative processes on the gastrointestinal mucosa.